Figure 4
From: Caffeine exacerbates seizure-induced death via postictal hypoxia
Acute caffeine administration decreases time to terminal apnea hypoxia and death. Representative profile from three C57BL/6J + kainic acid mice. (A,Ai) The mean time to terminal hypoxia of the hippocampus (HPC) was 51.93 ± 2.47 in vehicle (n = 11), 26.22 ± 2.58 in caffeine (n = 11) and 94.45 ± 10.11 in CGS-21680 (n = 11) mice ANOVA F (2,30) = 30.98, p =  < 0001***. (B,Bi) Mean time to terminal hypoxia of the pre-Bötzinger complex (PBC) was 52.32 ± 2.49 in vehicle, 26.37 ± 2.70 in caffeine and 101.2 ± 10.10 in CGS-21680 mice ANOVA F (2,30) = 37.46, p =  < 0.001****. (C,Ci) Mean time to terminal apnea in was 52.80 ± 2.52 in vehicle, 27.21 ± 2.65 in caffeine and 103.4 ± 10.01 in CGS-21680 mice ANOVA F (2,30) = 39.67, p =  < 0.0001****. (D,Di) Mean time to terminal asystole was 58.70 ± 2.69 in vehicle, 32.91 ± 2.61 in caffeine and 109.6 ± 9.92 in CGS-21680 mice ANOVA F (2,30) = 40.49, p =  < 0.0001****. Box plots represent mean ± SEM.
