Figure 5
From: Caffeine exacerbates seizure-induced death via postictal hypoxia
Chronic caffeine accelerates time to death and chronic CGS-21680 delays death. (A,B) (A) Kcna1−/− mice treated with caffeine (n = 9) lived significantly shorter compared to vehicle (n = 9) treated mice. Median survival day for vehicle mice was 42d compared to median survival of caffeine treated of 37d p = 0.0015** (Log-rank test) (Ai). Mean survival day for vehicle treated mice was 41.89 ± 0.99 compared to mean survival of caffeine treated mice 37 ± 0.72, t16 = 3.97, p = 0.0011**. Chronic CGS-21680 reduces premature mortality and extends life, while chronic caffeine increases premature mortality. (B) Kcna1−/− mice treated with CGS-21680 (n = 9) lived significantly longer compared to vehicle (n = 9) treated mice. Median survival day for vehicle mice was 44d compared to median survival of CGS-21680 of 51d ****p = < 0.0001 (Log-rank test), (Bi) Mean survival day for vehicle treated mice was 44 ± 0.52 compared to mean survival of CGS-21680 treated mice 51.78 ± 1.05, t16 = 6.61, p = < 0.0001****. Histobars represent mean ± SEM.
