Figure 3 | Scientific Reports

Figure 3

From: Interlukin-4 weakens resistance to stress injury and megakaryocytic differentiation of hematopoietic stem cells by inhibiting Psmd13 expression

Figure 3

IL-4 induces Psmd13 down-regulation. (A) qRT-PCR of the relative expression of Psmd13 in LKS+ cells from AML and control mice (n = 3 mice per group). (B) Histograms showing Psmd13 mRNA expression in LKS + cells with or without mIL-4 (10 ng/mL) and anti-IL4 (10 μg/mL) treatment for 24 h. N = 3 per group. (C) The gene expression profile of Psmd13 in HSPC subsets in ‘‘Gene Expression Commons’’ (https://gexc.stanford.edu). Calculated low/high expression level was represented by a color-coded heatmap: red represents high expression, white represents threshold level expression, and blue represents low expression. Data are shown as mean ± SD. *p < 0.05, ***p < 0.001. ns no significance.

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