Figure 2
From: Omarigliptin inhibits brain cell ferroptosis after intracerebral hemorrhage
MK3102 treatment alleviates brain damage after ICH in mice. (A) Representative microphotographs of HE staining at 3 days after ICH. Scale bar, 200 μm. (B) Quantitative analysis of brain damage area (n = 3 per group). (C,D) Quantitative analysis of neurological scores and corner test scores at 3 days after ICH (n = 10 per group). (E) Representative microphotographs of TUNEL positive cells, NeuN positive cells, TUNEL and NeuN double positive cells in the right brain hemisphere. Note that NeuN staining was not uniform in the sham and MK3102 group tissue because of some degree of injury caused by the sterile saline injection. Scale bar, 20 μm. (F,G) Quantitative analysis of TUNEL positive cells and TUNEL positive neurons in the right brain hemisphere at 3 days after ICH (n = 5 per group). All data are displayed as mean ± SD. The difference between groups was analyzed using One-way ANOVA test. **p < 0.01, ***p < 0.001, ****p < 0.0001 compared with sham and MK3102 group. #p < 0.05 compared with the ICH + DMSO group.
