Table 2 PD motor subtypes: demographic and clinical characteristics.

From: Autonomic function and motor subtypes in Parkinson’s disease: a multicentre cross-sectional study

 

Indeterminate (n = 74)

PIGD (n = 297)

TD (n = 343)

p Value

Age, years (median [IQR])

62.71 [56.22, 68.75]*

67.00 [62.00, 71.00]

63.18 [56.80, 69.02]*

 < 0.001

Gender female, n (%)

29 (39.18)

125 (42.09)

122 (35.56)

0.239

Education, years (median [IQR])

14.00 [10.25, 16.00] *

11.00 [9.00, 14.00]

16.00 [13.00, 18.00] *

 < 0.001

Duration, years (median [IQR])

0.57 [0.26, 2.04] *

3.14 [0.75, 6.60]

0.40 [0.22, 1.01] *

 < 0.001

Age of onset, years (median [IQR])

59.84 [53.03, 67.40]

62.00 [56.14, 67.00]

61.08 [54.85, 66.82]

0.252

Hoehn and Yahr stage, n (%)

  

 < 0.001

 Stage 1

21 (28.38)a

59 (19.87)

158 (46.06)*

 

 Stage 1.5

15 (20.27)a

66 (22.22)

12 (3.50)*

 

 Stage 2

36 (48.65)

107 (36.03)

172 (50.15)*

 

 Stage ≥ 2.5

2 (2.70)*

36 (21.89)

1 (0.30)*

 

MDS-UPDRS I score (mean (SD))

4.73 (3.65)*

3.66 (3.44)

4.67 (3.82)*

0.001

MDS-UPDRS II score (mean (SD))

7.97 (4.16)*a

9.89 (5.27)

5.36 (3.85)*

 < 0.001

MDS-UPDRS III score (mean (SD))

15.89 (8.32)

15.85 (7.15)

19.32 (9.74)*

 < 0.001

MDS-UPDRS IV score (mean (SD))

0.30 (0.57)*

1.26 (1.74)

0.07 (0.30)*

 < 0.001

LED, mg/day (mean (SD))

108.45 (179.77) *a

329.74 (282.84)

39.94 (117.67) *

 < 0.001

MOCA score (median [IQR])

26.00 [25.00, 28.00]

25.00 [24.00, 25.00]

27.00 [25.00, 29.00]*

 < 0.001

Depression, n (%)

36 (48.65)*

236 (79.46)

78 (22.74)*

 < 0.001

EDS, n (%)

11 (14.86)

27 (9.09)

42 (12.24)

0.259

pRBD, n(%)

20 (27.03)

61 (20.54)

111 (32.36)*

0.003

  1. Abbreviations: PD Parkinson’s disease, PIGD postural instability and gait disturbance, TD tremor dominant, MDS-UPDRS Movement Disorder Society revision of the Unified Parkinson’s Disease Rating Scale, MOCA Montreal Cognitive Assessment, EDS excessive daytime sleepiness, pRBD probable rapid eye movement sleep behavior disorder, SCOPA-AUT Scales for Outcomes in Parkinson’s Disease–Autonomic Dysfunction, IQR interquartile range, SD standard deviation.
  2. *p < 0.05 compared with the PIGD subtype.
  3. ap < 0.05 compared with the tremor-dominant subtype.
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