Table 2 Relative abundance (≥ 1%) at genus levels in patients with SVR and non-SVR at baseline and FUw72.

From: Long-term benefit of DAAs on gut dysbiosis and microbial translocation in HCV-infected patients with and without HIV coinfection

Genus

SVR (n = 66)

P-values

Non-SVR (n = 3)

P-values

Baseline

FUw72

Baseline

FUw72

Increasing bacteria in SVR group

 Blautia

0.018 ± 0.02

0.073 ± 0.04

 < 0.001**

0.017

0.069

0.109

 Bifidobacterium

0.002 ± 0.01

0.028 ± 0.06

 < 0.001**

0.006

0.104

0.109

 Subdoligranulum

0.003 ± 0.01

0.012 ± 0.02

 < 0.001**

0.025

0.014

0.593

 Dorea

0.005 ± 0.00

0.014 ± 0.01

 < 0.001**

0.006

0.013

0.593

 Megamonas

0.001 ± 0.01

0.007 ± 0.06

0.002*

0.019

0.059

1.000

 Collinsella

0.000 ± 0.00

0.043 ± 0.02

 < 0.001**

0.000

0.019

0.285

 Ruminococcus torques group

0.004 ± 0.01

0.014 ± 0.02

 < 0.001**

0.011

0.022

1.000

 Fusicatenibacter

0.002 ± 0.01

0.013 ± 0.02

 < 0.001**

0.014

0.031

0.109

 Streptococcus

0.001 ± 0.00

0.006 ± 0.01

 < 0.001**

0.001

0.013

0.285

 Eubacterium hallii group

0.003 ± 0.00

0.014 ± 0.01

 < 0.001**

0.003

0.019

0.109

 Coprococcus

0.003 ± 0.01

0.010 ± 0.02

 < 0.001**

0.009

0.012

1.000

 Anaerostipes

0.001 ± 0.00

0.006 ± 0.01

 < 0.001**

0.002

0.014

0.109

 Megasphaera

0.000 ± 0.00

0.000 ± 0.01

0.006*

0.004

0.024

1.000

 Holdemanella

0.000 ± 0.00

0.000 ± 0.02

0.004*

0.000

0.032

0.180

Decreasing bacteria in SVR group

 Bacteroides

0.170 ± 0.33

0.090 ± 0.14

 < 0.001**

0.087

0.155

0.593

 Lachnoclostridium

0.013 ± 0.02

0.009 ± 0.02

0.034*

0.024

0.012

0.109

 Sutterella

0.015 ± 0.02

0.010 ± 0.01

0.036*

0.023

0.014

0.593

 Lachnospira

0.007 ± 0.01

0.004 ± 0.01

0.033*

0.016

0.008

0.285

 Eubacterium eligens group

0.006 ± 0.01

0.002 ± 0.01

0.002*

0.011

0.000

0.180

  1. Data shown in median ± IQR
  2. SVR, Sustained virological response rates; FUw72, follow-up week-72
  3. *P < 0.05, **P < 0.001 (Wilcoxon Signed Ranks Test)