Figure 2 | Scientific Reports

Figure 2

From: Whole-brain characterization of apoptosis after sevoflurane anesthesia reveals neuronal cell death patterns in the mouse neonatal neocortex

Figure 2

Characterization of neocortical apoptosis after sevoflurane anesthesia at P7. (a) Anatomical gradients of c-caspase-3 staining volume fraction, n = 10. (b) Examples of fluorescence images acquired in the neocortex showing the intracortical distribution of c-caspase-3 positive cells. (c) Quantification of the distribution of intracortical c-caspase-3 positive cells, n = 14 (dorsal), 15 (lateral), 10 (ventral). (d) Examples of fluorescence images acquired after immunostainings for intracortical characterization of c-caspase-3 positive cells. Boxes show higher magnification images in single channels. (e) Quantification of the fraction of cortical cells co-staining with c-caspase-3, n = 65 (left), 41 (right). *p ≤ 0.05; ****p ≤ 0.0001. Data are presented as median (± IQR) except in e. for which data are presented as mean (± s.d.).

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