Table 3 Cox hazards model analysis of variables regarding histologic lesion scores for ESKD during follow-up in patients AAV-GN.

From: Renal histopathological predictors of end-stage kidney disease in ANCA-associated vasculitis with glomerulonephritis: a single-centre study in Korea

Variables

Univariable

Multivariable

HR

95% CI

P value

HR

95% CI

P value

Acute tubular injury

0.688

0.387, 1.223

0.202

   

Medullary angiitis

1.037

0.577, 1.863

0.903

   

Arterial intimal fibrosis

1.600

0.903, 2.834

0.108

   

Arterial medial sclerosis

1.933

0.903, 4.135

0.089

   

Interstitial inflammation

1.216

0.688, 2.152

0.501

   

Tubulitis

1.070

0.598, 1.912

0.820

   

Vasculitis

0.562

0.201, 1.570

0.272

   

Glomerulitis

1.061

0.381, 2.955

0.910

   

Peritubular capillaritis

1.137

0.642, 2.013

0.661

   

Total inflammation

1.215

0.684, 2.161

0.506

   

Inflammation in IFTA

1.026

0.578, 1.822

0.930

   

GBM double contour

0.726

0.100, 5.272

0.752

   

Arteriolar hyalinosis

5.576

0.746, 41.663

0.094

   

Arteriosclerosis

1.501

0.780, 2.889

0.224

   

Interstitial fibrosis

2.074

1.171, 3.674

0.012

1.335

0.638, 2.792

0.443

Tubular atrophy

2.259

1.274, 4.066

0.005

1.878

0.898, 3.927

0.094

Mesangial hypercellularity

0.506

0.070, 3.671

0.501

   

Global glomerulitis

3.311

1.520, 7.209

0.003

3.164

1.440, 6.949

0.004

Glomerular fibrinoid necrosis

0.726

0.402, 1.312

0.289

   
  1. ESKD end-stage kidney disease, AAV ANCA-associated vasculitis, ANCA antineutrophil cytoplasmic antibody, GN glomerulonephritis, UPIGN unclassifiable pauci-immune glomerulonephritis, IFTA interstitial fibrosis and tubular atrophy.
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