Figure 2 | Scientific Reports

Figure 2

From: The inhibition of pancreatic cancer progression by K-Ras-overexpressing mesenchymal stem cell-derived secretomes

Figure 2

Tumor-suppressing capability of PI3K-activated MSC-derived CM. The single and double asterisks (comparison to CN) and pound signs (comparison to CM control) indicate p < 0.05 and 0.01, respectively. CM conditioned medium, CN control, YS YS49, PI3K activator. (A) Elevation of p-Akt by K-Ras-overexpressing Pa03C pancreatic cancer cells. (B) Suppression of MTT-based viability of PANC1, Pa03C, ASPC1, PANC10.05, and PANC198 pancreatic cancer cells by YS49-treated MSC-derived CM. (C,D) Suppression of scratch-based migration in PANC1 cells and Pa03C cells, respectively, by YS49-treated MSC-derived CM. (E) Reduction in cMyc, K-Ras, p-Akt, and Snail in PANC1 and Pa03C pancreatic cancer cells by YS49-treated MSC-derived CM. (F) Elevation of p-Akt in YS49-treated MSCs.

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