Figure 3
Suppression of Pa03C tumor cell growth by PI3K-activated MSC-derived CM. The single and double asterisks (comparison to CN) and pound signs (comparison to CM control) indicate p < 0.05 and 0.01, respectively. CM conditioned medium, CN control, YS YS49, PI3K activator. (A,B) Suppression of transwell invasion of PANC1 and Pa03C cells, respectively, by PI3K-activated MSC-derived CM. (C) HE-stained lung sections of NOD/SCID/γ(−/−) mice, showing the suppression of cell growth by YS49-treated MSC CM. Pa03C cells were inoculated from the tail vein (N = 5). (D) Fluorescently labeled lung sections of three mouse groups. Pa03C cells were labeled with red fluorescent proteins and all nuclei were stained with DAPI.
