Figure 8 | Scientific Reports

Figure 8

From: Label-free drug response evaluation of human derived tumor spheroids using three-dimensional dynamic optical coherence tomography

Figure 8

Schematic depictions of two D-OCT algorithms:(a) LIV and (b) OCDS\(_l\). LIV is defined as the temporal fluctuation (variance) of the dB-scaled OCT intensity. As a result, LIV is expected to be sensitive to the magnitude of the tissue dynamics. On the other hand, OCDS\(_l\) represents the speed of the dynamics and is defined as the decorrelation rate, i.e., as the slope of the auto-correlation curve [red curve in (b)] of the dB-scaled OCT intensity. The slope is computed here by performing a linear regression of the auto-correlation curve over a specified delay-time range [204.8, 1,228.8 ms].

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