Figure 2
From: New drug discovery of cardiac anti-arrhythmic drugs: insights in animal models
The ventricular action potential and ionic currents in humans and mice. Note the differences in action potential shape, which is caused primarily by differences in ionic currents circled in red. ICa(L) indicates L-type Ca current; ICa(T), T-type Ca current; INa, Na current; INaCa, Na-Ca-Exchange current; INaK, NaK-ATPase pump current; IK1, Inward rectifier K-current; IKr, rapidly activating delayed rectifier K-current; IKs, slowly activating delayed rectifier K-current; Iss, rapidly activating steady-state K-currents; and Ito, transient outward K-current. Please note that current densities (pA/pF) measured in single cells vary drastically with experimental conditions and voltage clamp protocols. Current densities were chosen to reflect relative contributions to the AP. [Daniel J. Blackwell. Circulation Research. Animal Models to Study Cardiac Arrhythmias, Volume: 130, Issue: 12, Pages: 1926–1964 (https://doi.org/10.1161/CIRCRESAHA.122.320258)].
