Figure 2 | Scientific Reports

Figure 2

From: Epigenomic analysis reveals a unique DNA methylation program of metastasis-competent circulating tumor cells in colorectal cancer

Figure 2

DNA methylation profiles of CpGIs and shore regions of gene promoters in CTC-MCC-41 compared to HT29 primary tumor cells. (A) Hierarchical clustering heatmap of the 10,000 most differentially methylated CpGs (FDR adjusted p value < 0.05) in CTC-MCC-41 with respect to HT29 and located at CpGIs and shore regions of gene promoters. Heatmap shows three different passages (P) of CTC-MCC-41 (P12, P13 and P14) and HT29 (P2, P3 and P4). (B) Gene Ontology (GO) analysis representing some of the most cancer-relevant biological processes and Panther pathways based on the 10,000 most differentially methylated CpGs of CTC-MCC-41 compared to HT29 and located at CpGIs and shore regions of gene promoters.

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