Table 1 Comparison of the analyzed clinical and laboratory data in ALS patients stratified by FVC.
From: Venous blood parameters in determination of respiratory impairment in amyotrophic lateral sclerosis
Variable | The retrospective cohort | The prospective cohort | ||||||
|---|---|---|---|---|---|---|---|---|
Total | FVC: normal | (Male and FVC < 3.062) or (female and FVC < 2.266) | P | Total | FVC: normal | (Male and FVC < 3.062) or (female and FVC < 2.266) | P | |
Gender | 319 | 187 | 132 | 97 | 58 | 39 | ||
Male | 230 | 138 (73.80%) | 92 (69.70%) | 0.421 | 59 | 33 (56.90%) | 26 (66.67%) | 0.334 |
Female | 89 | 49 (26.20%) | 40 (30.30%) | 38 | 25 (43.10%) | 13 (33.33%) | ||
Age (year) | 319 | 51.75 ± 9.72 | 59.71 ± 10.83 | < 0.001 | 97 | 52.53 ± 11.00 | 61.64 ± 10.46 | < 0.001 |
Onset age (year) | 319 | 50.62 ± 9.77 | 58.35 ± 11.19 | < 0.001 | 97 | 51.67 ± 10.95 | 60.44 ± 10.52 | < 0.001 |
Hypertension | 315 | 184 | 131 | 97 | 58 | 39 | ||
SBP (mmHg) | 315 | 130.00 (23.00) | 130.00 (25.00) | 0.387 | 97 | 125.00 (25.00) | 132.00 (35.00) | 0.319 |
DBP (mmHg) | 315 | 88.00 (17.00) | 84.00 (19.00) | 0.022 | 97 | 81.43 ± 12.42 | 86.21 ± 14.02 | 0.486 |
Weight (kg) | 319 | 63.00 (14.00) | 55.00 (10.75) | < 0.001 | 97 | 60.19 ± 8.96 | 55.00 ± 8.87 | 0.006 |
Height (m) | 319 | 1.63 ± 0.08 | 1.58 ± 0.07 | < 0.001 | 97 | 1.61 ± 0.07 | 1.59 ± 0.08 | 0.110 |
BMI (kg/m2) | 319 | 23.26 ± 3.02 | 21.81 ± 2.84 | < 0.001 | 97 | 23.03 ± 2.57 | 21.79 ± 3.29 | 0.041 |
Site of onset | 319 | 187 | 132 | 97 | 58 | 39 | ||
Limb onset | 259 | 159 (85.03%) | 100 (75.76%) | 0.092 | 75 | 46 (79.31%) | 29 (74.36%) | 0.568 |
Bulbar onset | 51 | 23 (12.30%) | 28 (21.21%) | 22 | 12 (20.69%) | 10 (25.64%) | ||
Other | 9 | 5 (2.67%) | 4 (3.03%) | 0 | 0 | 0 | ||
Diagnostic level | 319 | 187 | 132 | 97 | 58 | 39 | ||
Probable | 155 | 94 (50.27%) | 61 (46.21%) | 0.475 | 70 | 44 (75.86%) | 26 (66.67%) | 0.322 |
Definite | 164 | 93 (49.73%) | 71 (53.79%) | 27 | 14 (24.14%) | 13 (33.33%) | ||
Disease duration (m) | 319 | 11.00 (11.00) | 12.00 (17.00) | 0.072 | 97 | 11.50 (10.00) | 12.00 (18.00) | 0.205 |
PLT (109/L) | 319 | 183.00 (80.00) | 183.00 (70.75) | 0.815 | 97 | 168.00 (75.25) | 186.00 (65.00) | 0.079 |
WBC (109/L) | 319 | 5.83 (1.97) | 5.83 (2.36) | 0.412 | 97 | 5.31 (1.69) | 5.36 (1.83) | 0.965 |
NEUT# (109/L) | 319 | 3.39 (1.60) | 3.41 (1.54) | 0.826 | 97 | 3.21 ± 0.98 | 3.40 ± 1.14 | 0.401 |
LYMPH# (109/L) | 319 | 1.82 (0.58) | 1.64 (0.79) | 0.007 | 97 | 1.60 (0.82) | 1.41 (0.84) | 0.106 |
PLR | 319 | 101.72 (51.15) | 114.58 (67.12) | 0.023 | 97 | 95.49 (63.58) | 127.45 (84.11) | 0.037 |
NLR | 319 | 1.87 (1.10) | 2.05 (1.00) | 0.116 | 97 | 1.91 (0.95) | 2.04 (1.45) | 0.131 |
MONO# (109/L) | 319 | 0.41 (0.18) | 0.39 (0.15) | 0.595 | 97 | 0.38 (0.15) | 0.39 (0.18) | 0.962 |
EO# (109/L) | 318 | 0.12 (0.12) | 0.11 (0.12) | 0.296 | 97 | 0.15 (0.16) | 0.12 (0.15) | 0.306 |
BASO# (109/L) | 318 | 0.03 (0.02) | 0.03 (0.02) | 0.834 | 97 | 0.02 (0.02) | 0.02 (0.01) | 0.29 |
ALB (g/L) | 319 | 42.70 (4.40) | 42.20 (4.68) | 0.144 | 97 | 42.15 (3.88) | 41.90 (4.90) | 0.991 |
GLU (mmol/L) | 319 | 4.72 (0.83) | 4.94 (0.69) | 0.018 | 97 | 4.68 (0.70) | 4.72 (0.84) | 0.659 |
UREA (mmol/L) | 319 | 5.00 (1.50) | 5.30 (2.08) | 0.154 | 97 | 5.50 (2.03) | 5.50 (2.30) | 0.664 |
CREA (µmol/L) | 319 | 62.00 (16.00) | 56.00 (19.00) | < 0.001 | 97 | 61.00 (19.25) | 59.00 (33.00) | 0.985 |
URIC (µmol/L) | 319 | 311.00 (86.00) | 303.50 (103.25) | 0.449 | 97 | 291.00 (101.50) | 280.00 (114.00) | 0.749 |
TG (mmol/L) | 319 | 1.33 (1.04) | 1.15 (0.68) | 0.004 | 97 | 1.32 (0.95) | 1.12 (0.43) | 0.050 |
CHOL (mmol/L) | 319 | 4.60 ± 0.86 | 4.66 ± 0.90 | 0.566 | 97 | 4.42 ± 0.83 | 4.69 ± 1.08 | 0.165 |
CK (mmol/L) | 319 | 165.00 (209.00) | 170.50 (183.50) | 0.984 | 97 | 143.00 (137.75) | 104.00 (103.00) | 0.109 |
LDL (mmol/L) | 319 | 2.73 ± 0.73 | 2.69 ± 0.79 | 0.651 | 97 | 2.66 ± 0.69 | 2.83 ± 0.87 | 0.276 |
HDL (mmol/L) | 319 | 1.19 (0.42) | 1.34 (0.50) | < 0.001 | 97 | 1.21 (0.33) | 1.31 (0.39) | 0.025 |
LDL/HDL | 319 | 2.38 (1.07) | 2.08 (1.05) | 0.001 | 97 | 2.19 (0.92) | 1.90 (1.19) | 0.199 |
CCI | 319 | 0.00 (0.00) | 0.00 (1.00) | 0.056 | 97 | 0.00 (0.00) | 0.00 (0.00) | 0.690 |
