Table 5 Performance of Xpert monitor to predict the need for 2nd TURB.
From: Xpert bladder cancer monitor to predict the need for a second TURB (MoniTURB trial)
Group | n | TP | FP | TN | FN | Sensitivity | Specificity | HG | LG | PPV | NPV |
|---|---|---|---|---|---|---|---|---|---|---|---|
(a) Total cohort (n = 171) | |||||||||||
Control cystoscopy | 56 | 2 | 18 | 36 | 0 | 2/2 (100%) | 36/54 (66.7%) | 2/2 (100%) | 2/20 (10%) | 36/36 (100%) | |
2nd TURB | 112 | 28 | 44 | 34 | 6 | 28/34 (82.4%) | 34/78 (43.6%) | 24/28 (85.7%) | 4/6 (66.7%) | 28/72 (38.9%) | 34/40 (85.0%) |
Total | 168 | 30 | 62 | 70 | 6 | 30/36 (83.3%) | 70/132 (53.0%) | 24/28 (85.7%) | 6/8 (75%) | 30/92 (32.6%) | 70/76 (92.1%) |
(b) Patients with muscle in specimen at initial TURB (n = 131) | |||||||||||
Control cystoscopy | 36 | 1 | 15 | 20 | 0 | 1/1 (100%) | 20/35 (57.1%) | 1/1 (100%) | 1/16 (6.3%) | 20/20 (100%) | |
2nd TURB | 93 | 24 | 37 | 28 | 4 | 24/28 (85.7%) | 28/65 (43.1%) | 20/24 (83.3%) | 4/4 (100%) | 24/61 (39.3%) | 28/32 (87.5%) |
Total | 129 | 25 | 52 | 48 | 4 | 25/29 (86.2%) | 48/100 (48%) | 20/24 (83.3%) | 5/5 (100%) | 25/77 (32.5%) | 48/52 (92.3%) |
(c) Patients with pTa tumor at initial TURB (n = 115) | |||||||||||
Control cystoscopy | 54 | 2 | 16 | 36 | 0 | 2/2 (100%) | 36/52 (69.2%) | 2/2 (100%) | 2/18 (11.1%) | 36/36 (100%) | |
Second TURB | 59 | 14 | 25 | 19 | 1 | 14/15 (93.3%) | 19/44 (43.2%) | 11/11 (100%) | 3/4 (66.7%) | 14/39 (35.9%) | 19/20 (95.0%) |
Total | 113 | 16 | 41 | 55 | 1 | 16/17 (83.3%) | 55/96 (57.3%) | 11/11 (100%) | 5/6 (83.3%) | 16/57 (28.1%) | 55/56 (98.2%) |
