Table 3 Validation metrics of ABRicate and ResFinder tools for resistance genes.

From: Pipeline validation for the identification of antimicrobial-resistant genes in carbapenem-resistant Klebsiella pneumoniae

Tool

Gene

Metric

1

2

3

4

5

6

7

ABRicate

Carbapenem resistance genes

Repeatability

100%

100%

100%

100%

100%

100%

100%

Reproducibility

100%

Accuracy

99.99%

99.99%

100%

100%

100%

99.98%

100%

Precision

90.19%

95.45%

100%

100%

100%

100%

0

Sensitivity

92.00%

82.89%

100%

100%

100%

55.55%

0

Specificity

99.99%

99.99%

100%

100%

100%

100%

100%

All antimicrobial resistance genes

Repeatability

100%

100%

100%

100%

100%

100%

100%

Reproducibility

44.92%

Accuracy

99.88%

99.88%

99.97%

99.94%

99.97%

99.85%

100%

Precision

93.79%

97.76%

96.85%

95.95%

97.39%

100%

100%

Sensitivity

74.28%

79.59%

96.63%

90.97%

97.90%

72.36%

100%

Specificity

99.98%

99.99%

99.98%

99.98%

99.98%

100%

100%

ResFinder

Carbapenem resistance genes

Repeatability

100%

100%

100%

100%

100%

100%

100%

Reproducibility

100%

Accuracy

99.99%

99.99%

100%

100%

100%

99.98%

100%

Precision

91.07%

95.45%

100%

100%

100%

100%

0

Sensitivity

92.72%

82.89%

100%

100%

100%

55.55%

0

Specificity

99.99%

99.99%

100%

100%

100%

100%

100%

All antimicrobial resistance genes

Repeatability

100%

100%

100%

100%

100%

100%

100%

Reproducibility

36.23%

Accuracy

99.80%

99.79%

99.94%

99.86%

99.97%

99.84%

100%

Precision

90.44%

89.12%

92.14%

90.96%

97.79%

100%

100%

Sensitivity

72.88%

79.36%

96.75%

85.93%

98.51%

76.92%

100%

Specificity

99.95%

99.93%

99.95%

99.94%

99.98%

100%

100%