Table 3 Univariate and multivariate analyses of clinical parameters for increased ionized calcium concentration.
From: Risk analysis of fluctuating hypercalcemia after leukapheresis in cellular therapy
Univariate | Multivariate | ||||||||
|---|---|---|---|---|---|---|---|---|---|
Coefficient | LO_95%CI | UP_95%CI | p value | Coefficient | LO_95%CI | UP_95%CI | p value | ||
Patient background | |||||||||
Age | /year | 0.314 | − 0.069 | 0.697 | 0.107 | ||||
Sex | Female vs. male | 0.196 | − 0.070 | 0.462 | 0.146 | ||||
Height | /cm | −2.039 | − 4.899 | 0.821 | 0.160 | ||||
Body weight | /kg | −0.448 | − 1.317 | 0.420 | 0.307 | ||||
TBV | /dL | −0.598 | − 1.418 | 0.223 | 0.151 | ||||
Type of leukapheresis | Auto-PB vs. allo-PB | 0.240 | − 0.287 | 0.768 | 0.366 | ||||
CAR-T vs. allo-PB | 0.298 | − 0.195 | 0.790 | 0.232 | |||||
Laboratory baseline | |||||||||
Hct | /% | −0.081 | − 0.817 | 0.654 | 0.826 | ||||
Alb | /g/dL | −0.249 | − 1.435 | 0.938 | 0.677 | ||||
T-Bil | /mg/dL | −0.126 | − 0.435 | 0.183 | 0.420 | ||||
eGFR | /mL/min/1.73 m2 | −0.348 | − 0.822 | 0.126 | 0.148 | ||||
pH | 26.656 | − 14.018 | 67.330 | 0.196 | |||||
iCa | /mg/dL | 0.990 | − 1.881 | 3.861 | 0.494 | ||||
tCa | /mg/dL | −0.080 | − 3.605 | 3.445 | 0.964 | ||||
Leukapheresis parameters | |||||||||
Blood volume processed/body weight | /L/kg | 0.553 | 0.060 | 1.047 | 0.028* | 0.425 | 0.057 | 0.793 | 0.024* |
Duration of leukapheresis | /min | −0.340 | − 0.881 | 0.201 | 0.214 | ||||
Dose of ACD-A | /mL | 0.548 | 0.007 | 1.089 | 0.047* | ||||
Calcium supplementation rate | /mg/min | 1.254 | 0.598 | 1.909 | < 0.001* | 0.586 | 0.048 | 1.123 | 0.033* |
Laboratory at the end of leukapheresis | |||||||||
pH | 4.195 | − 29.392 | 37.783 | 0.804 | |||||
iCa | /mg/dL | −3.674 | − 4.631 | − 2.716 | < 0.001* | − 3.383 | − 4.307 | − 2.458 | < 0.001* |
tCa | /mg/dL | 4.054 | 1.575 | 6.532 | 0.002* | ||||
