Figure 6

Effects of the alendronate column on left ventricular hypertrophy. Left ventricular hypertrophy was evaluated using 3D-CT images of the formalin-fixed hearts (a). Arrows indicate ectopic calcification. (b,c) The treatment group had significantly greater left ventricular wall thickness (LVWT) and left ventricular mass index (LVMI) than the control group (N = 4 for each group, **P < 0.01, by Student’s t test). LVWT was calculated using the following formula: \(\sqrt{A1/\pi }- \sqrt{A2/\pi }\), where A1 and A2 represent the area as defined in (b).