Figure 5
Transcriptome analysis of osteoclast differentiation in PPMX. (A) The 20 most enriched KEGG pathways based on DEGs at E15.5 vs. E14.5 and E16.5 vs. E15.5. The x-axis shows the enrichment factor, and the y-axis shows the pathway names. The point size represents the number of genes enriched in a particular pathway. (B) GSEA for osteoclast differentiation (mmu04380) on E15.5 vs E14.5, E16.5 vs E15.5 and E16.5 vs E14.5. *Represents significant enrichment of GSEA. (C) Volcano plot of OCL differentiation (mmu04380) DEGs on E15.5 vs E14.5, E16.5 vs E15.5 and E16.5 vs E14. 5. Red dots represent upregulated DEGs, and blue dots represent downregulated DEGs. (D) Heatmap showing the DEG expression (Z scores) of osteoclast differentiation (mmu04380) at E14.5, E15.5 and E16.5. (E) KEGG pathway map of osteoclast differentiation (mmu04380) at E16.5 compared with E14.5. Red boxes represent upregulated DEGs, and green boxes represent downregulated DEGs.
