Figure 6 | Scientific Reports

Figure 6

From: IL-1β stimulated human umbilical cord mesenchymal stem cells ameliorate rheumatoid arthritis via inducing apoptosis of fibroblast-like synoviocytes

Figure 6

Therapeutic efficacy evaluation of hUCMSCs in CIA mouse model. (a) The group of CIA mouse models. Sham: without collagen induction, RA: CIA mice without hUCMSCs administration, hUCMSCs: CIA mice with 1 × 106 hUCMSCs administration, IL-1β stimulated hUCMSCs: CIA mice with 1 × 106 IL-1β stimulated hUCMSCs. (b) The timeline of RA induction and hUCMSCs administration. Mice were randomly divided into four groups on day 36 after the first immunization. (c) Statistical results of arthritis score after hUCMSCs administration. (d) Statistical results of paw thickness after hUCMSCs administration. The data represent mean ± SD (n = 7 per group) (*P < 0.05, **P < 0.01, ***P < 0.001).

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