Figure 1 | Scientific Reports

Figure 1

From: A 3D adrenocortical carcinoma tumor platform for preclinical modeling of drug response and matrix metalloproteinase activity

Figure 1

A depiction of the overall workflow of the study. NCI-H295R ACC cells are used either as traditional 2D cell cultures or ECM hydrogel-based 3D tumor constructs. The culture models were then characterized through histology and IF and deployed within chemotherapy screens. The 3D constructs were also functionalized with MMP-sensitive fluorogenic peptide biosensors to evaluate cellular MMP activity within the 3D ECM hydrogel, or implemented within a metastasis-on-a-chip platform.

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