Figure 5
From: Repeated episodes of postictal hypoxia are a mechanism for interictal cognitive impairments
Interictal memory impairments induced by kindling are long-lasting and can be prevented by blocking repeated PIH. Hippocampal—dependent novel object/context-mismatch task was performed in rats 24 h and 2 weeks after the last seizure. (a) Schematic representation of novel object/context-mismatch task. (b) Quantification of discrimination index. The horizontal red dashed line represents a discrimination index of 0.5. Values above 0.5 indicates greater investigation of the novel object, thus preserved memory formation. The Shapiro–Wilk test indicated data are normally distributed. Data are shown as mean ± SEM (n = 4–9 each group), followed by one-way ANOVA and Sidak's post hoc test (*p < 0.05; **p < 0.01; ***p < 0.001). (c) Scatterplot of the relationship between the degree of severe hypoxia expressed as the sum of the total area below the severe hypoxic threshold (10.0 mmHg) by time (min) over kindling and the discrimination index. The line of best fit (Y = − 8.306e−005 × X + 0.6411) is indicated. R2 = 0.35, p = 0.0007. Veh vehicle, Sz seizure, Ace acetaminophen, Nifed nifedipine, No Sz no seizure, Wks weeks.
