Table 5 Categorization of potential biomarker from top 100 targets for Asthma.
From: In-silico identification and prioritization of therapeutic targets of asthma
Target | Expression or secretion in | Role in Asthma |
|---|---|---|
Diagnostic biomarkers | ||
IL13 | Serum, Sputum46 | Induce chemotaxis of eosinophils to the site of injury51 |
TNF | Pro-inflammatory cytokine and recruitment of neutrophils and eosinophils52 | |
ADIPOQ | Plasma, lung53 | It is a modulator of the innate and acquired immunity response54 |
CCL26 | Sputum55 | Recruits and activates eosinophils in asthmatic patients55,56 |
IL2 | Sputum, Serum, EBC57 | Regulates inflammatory response57 |
HMGB1 | Sputum58 | It plays a central role in eosinophilic airway inflammation in asthma59 |
CCL11 | BALF, Blood, EBC and sputum60 | Play important role in leukocyte migration into the lungs61 |
Prognostic biomarkers | ||
IL10 | Serum46 | Anti-inflammatory and involved in cytokine activation62 |
IFNG | Serum63 | IFNG stimulate eosinophil activation, longevity or apoptosis63 |
CRP | Serum64 | It is associated with Asthma severity and has role in Calcium ion binding65 |
MMP9 | BALF, Sputum66 | MMP-9 play a role in chronic airway inflammation and remodeling67 |
CD14 | Serum, Plasma68 | It is a marker of monocyte/macrophage activation69 |
FGF2 | Sputum70 | Important in tissue development and repair71 |
IL33 | Lung72 | IL-33 plays important roles in type-2 innate immunity73 |
CD86 | Blood74 | Contributes to T lymphocyte activation and expansion75 |
LEP | Serum 76 | Leptin is elevated in obese individuals, and the risk of asthma76 |
EPX | BW, BAL and serum77 | It is highly toxic to bacteria and parasites. It regulate inflammation78 |
GC | Sputum79 | It is important in vitamin D metabolic process and low levels of vitamin D are associated with asthma severity80 |
Therapeutic biomarker | ||
IGF1R | BAL81 | Regulating phagocytosis and communication of alveolar macrophages82 |
Diagnostic and prognostic biomarkers | ||
VEGFA | Serum83 | Plays an important role in the development of airway remodeling84 |
POSTN | Serum48 | Eosinophil recruitment, airway remodeling, development of a Th2 phenotype, and contributes to the increased expression of inflammatory mediators85 |
