Figure 2

Effects of topical administration of heat-killed KB131 on accumulation of leukocytes and synthesis of cytokines and chemokines. (A) The numbers of leukocytes, neutrophils, macrophages, and lymphocytes in the wound tissue were analyzed by flow cytometric analyses (n = 6 mice per group). (B) Production of CXCL1 (KC), CXCL2 (MIP-2), CCL2 (MCP-1), CCL3 (MIP-1a), CCL4 (MIP-1b), and CCL5 (RANTES) in the wound tissues at 6 h, 12 h, and days 1, 3, and 5 after wounding (n = 5 mice per group). Each column represents the mean ± SD. *p < 0.05, **p < 0.01. h hour; WT wild type.