Figure 8 | Scientific Reports

Figure 8

From: Chronic hyperpalatable diet induces impairment of hippocampal-dependent memories and alters glutamatergic and fractalkine axis signaling

Figure 8

Chronic consumption of HSB diet increases hippocampal fractalkine levels. (A) Schematic representation of fractalkine neuron-glial communication and the control effect of neurotrophic factors, and pre/post synaptic proteins in neuronal synaptic plasticity. (B,C) Quantification of mRNA levels of fractalkine receptor (CX3CR1), and fractalkine (CX3CL1). (D–G) Measurements of protein levels of CX3CL1, brain derived neurotrophic factor (BDNF), nerve growth factor (NGF), and glial derived neurotrophic factor (GDNF). (H–J) Measurements of mRNA levels of synaptophysin, postsynaptic density protein 95 (PSD-95), and activity-regulated cytoskeleton-associated protein (ARC). Error bars represent the mean ± SEM; n = 4 (F), 5 (D,E,G), and 9–10 (B,C,H–J). Unpaired two tail T-student test (B–E,H–J), and Mann–Whitney test (F–G). *p < 0.05.

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