Figure 3 | Scientific Reports

Figure 3

From: Noradrenaline depresses facial stimulation-evoked cerebellar MLI-PC synaptic transmission via α2-AR/PKA signaling cascade in vivo in mice

Figure 3

NA depresses MLI-PC synaptic transmission through α2-AR. (A) Representative traces showing air-puff stimulation-evoked responses in a cerebellar PC in ACSF, NA (15 µM), NA + Yohimbine (Yohim; 100 µM), and washout. (B) Summary of data shows the time course of normalized amplitude of P1 and P2 during treatments with ACSF, NA, NA + Yohim and washout. (C) Summary of data shows the time course of normalized amplitude of P1 and P2 during treatments with ACSF, NA (15 µM), NA + Prazosin (Praz; 50 µM) and washout. (D,E) Bar graphs show the normalized amplitude of P1 (D) and the normalized P2/P1 ratio (E) in treatments with ACSF, NA, NA + Yohim and washout. (F,G) Bar graphs show the normalized amplitude of P1 (F) and the normalized P2/P1 ratio (G) during each treatment, ACSF, NA, NA + Prazosin and washout. ***P < 0.001 vs. ACSF; n = 6 in each group.

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