Figure 5 | Scientific Reports

Figure 5

From: Noradrenaline depresses facial stimulation-evoked cerebellar MLI-PC synaptic transmission via α2-AR/PKA signaling cascade in vivo in mice

Figure 5

NA inhibits MLI-PC synaptic transmission through α2A- and α2B-AR subtypes. (A) Representative cell-attached recording traces showing air-puff stimulation (60 ms; 60 psi)-evoked responses in a cerebellar PC in ACSF, NA (15 µM), NA + BRL44408 (BRL; 50 µM), and washout. (B) Summary of data shows the time course of normalized amplitude of P1 and P2 during treatments with ACSF, NA, NA + BRL and washout. (C,D) Summary of data show the normalized amplitude of P1 (C) and the normalized P2/P1 ratio (D) during treatments with ACSF, NA, NA + BRL and recovery (washout). (E) Summary of data shows the time course of normalized amplitude of P1 during treatments with ACSF, NA (15 µM), NA + Imiloxan (IMI; 50 µM; grey) or NA + JP1302 (JP; 50 µM; white) and washout. (F,G) Bar graphs show the normalized amplitude of P1 (F) and P2/P1 ratio (G) in treatments with ACSF, NA, NA + Imiloxan and washout. (H,I) Bar graphs show the normalized amplitude of P1 (H) and P2/P1 ratio (I) during treatments with ACSF, NA, NA + JP1302 and washout. *P < 0.05, **P < 0.01 and ***P < 0.001 vs. ACSF; #P < 0.05, ##P < 0.01 and###P < 0.001 vs. NA; n = 6 in each group.

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