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Figure 1

From: NOXA expression is downregulated in human breast cancer undergoing incomplete pathological response and senescence after neoadjuvant chemotherapy

Figure 1

PAMIP1 (NOXA) gene expression in two publicly available datasets of breast tumors that were exposed to NAC. (A) PAMIP1 expression in a sample (GSE28844) of 33 invasive breast tumors before and after exposure to NAC (left panel). Of these, 28 were matched samples, collected before (pre-) and after (post-) NAC from each patient (right panel). In the matched set, 19 tumors showed reduced PAMIP1 expression (blue lines), while only 9 showed increased expression (orange lines) following exposure to NAC. (B) PAMIP1 expression in a sample (GSE21974) of 32 invasive breast tumors before (pre-) and after (post-) exposure to NAC (left panel), of which, 25 samples were matched (right panel). Similar to data in A, overall PAMIP1 gene expression post-NAC was reduced (left panel), and 17 of the 25 matched samples exhibited a reduction in PAMIP1 expression (blue lines), and only 8 had increased expression (orange lines) following exposure to NAC. Statistical differences were calculated using unpaired and paired t-tests. ns: not statistically significant; *: p value < 0.05; **: p value < 0.01; ***: p value < 0.001; ****: p value < 0.0001. NAC: neoadjuvant chemotherapy.

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