Figure 2
From: Evaluation of the NRF1-proteasome axis as a therapeutic target in breast cancer
Proteasome subunit gene signatures show increased expression across breast cancer subtypes when compared to normal breast tissue. Expression of the 26S proteasome (A), 20S catalytic core (B), and 19S regulatory subunit (C) gene signatures are increased in primary breast cancer tumor tissue compared to normal breast tissue (n = 291) across breast cancer subtypes. Data and graphs were generated by the GEPIA2 database. Each point represents a patient sample’s average expression for the gene signature; basal-like (n = 135), HER2-enriched (n = 66), luminal A (n = 415), and luminal B (n = 194).
