Table 2 Electrochemical biosensors for tau protein detection.
Technique | Sensing platform | Sample | Linear range | LOD | Refs. |
|---|---|---|---|---|---|
EIS | Ab/Protein G/3,3'-dithiobis(sulfosuccinimidyl propionate) (DTSSP)/Gold Electrode | BSA & Human serum | 0.01 pM to 10 nM | 0.03 pM | |
DPV | Aptamer-Au-CS bioconjugate /BSA/Ab/MPA/Gold Electrode | Human serum | 0.5 pM to 100 pM | 0.42 pM | |
EIS | 3-aminophenol MIP/C-SPE | PBS | 2.18 pM to 2.18 nM | 0.024 pM | |
EIS | n-butylamine/Ab/lipoic acid/Au Electrode | PBS | – | 100 μg/mL | |
DPV | carbon nanocomposite film composed of MWCNTs, rGO, and CS/Gold Electrode | Human serum | 0.5–80 fM | 0.46 fM | |
DPV | Apt/AuNPs/Paper-based vertical graphene electrode (VGE) | Blood | 0.1 pg/mL to 1 ng/mL | 0.034 pg/mL | |
SWV, CV | Ab/MWCNTs-PAH/Pt/C-SPE | Serum | 8.6–1100 pg/mL | 0.24 pg/mL | |
Amperometric | HRP-DAb/tau/capture antibody/AuNPs-PAMAM/C-SPE | Undiluted human plasma and brain tissue extracts | 11–800 pg mL | 1.7 pg mL–1 | |
SWV | Ab/rGO/GCE | Serum | 0.08 pM-80 pM | 75 fM | |
DPV | /carboxyl graphene/thionin/gold NPs/GCE | Serum | 1.0 pM to 100 pM | 0.70 pM | |
EIS | Ab/Flower-shaped TiO2/Gold Electrode | Serum | 1–200 ng/mL | 1.774 pg/mL | |
DPV, EIS | BSA/Ab/Pt@ZIF-8/GCE | Serum | 1 fg mL−1 to 10 ng mL−1 | 1 fg mL−1 | This work |
