Table 1 Pearson coefficient between CSE1L and genes of interest.

From: CSE1L is a negative regulator of the RB-DREAM pathway in p53 wild-type NSCLC and can be targeted using an HDAC1/2 inhibitor

 

Pearson coefficient (R)

p53 WT

p53 MUT

CSE1L

CSE1L

AURKA

0.63

0.56

AURKB

0.58

0.52

BUB1

0.69

0.56

BUB1B

0.74

0.54

CCNA2

0.64

0.52

CCNB1

0.59

0.52

CCNB2

0.70

0.49

CDK1

0.69

0.46

PLK1

0.66

0.55

PLK4

0.66

0.45

RB1

0.38

0.15

RBL1

0.72

0.52

RBL2

− 0.16

− 0.15

CDKN1A

− 0.17

− 0.12

  1. CSE1L positively correlates with DREAM-target genes and negatively with RBL2 and CDKN1A in NSCLC (TCGA). Gene expression (FPKM) in p53 WT (n = 295) and p53 MUT (n = 699) NSCLC was extracted from the TCGA database. Correlation between CSE1L and the indicated genes was analyzed with Pearson with Pearson coefficient indicated.
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