Figure 1

Manhattan plot. Regressions relating four genetic models (heterozygote = over-dominant) for high-frequency pretermination codon (PTC) single-nucleotide polymorphisms (SNPs) with body mass index. P-values for PTC-SNP rs67047829 are shown as large points on vertical black lines. SNP numbers are from the 139 SNPs in Supplementary Table S3. Significance levels are nominal (p = 0.05) or after Bonferroni correction.