Figure 1

In-depth SNP analysis of the PDGFRA gene region in the Japanese cohort. Data are shown for the cases with corneal astigmatism (a) ≤  − 1.25 D or (b) ≤  − 1.50 D. (Top row) Posterior inclusion probability for each SNP genotyped and imputed in the current study. (Middle row) Regional association plot for each SNP. The left y-axes represent the − log10 P values for associations with corneal astigmatism; the right y-axes represent the estimated recombination rate. The horizontal blue and red lines indicate P = 0.05 and Pc = 0.05 (i.e. P = 0.05/9), respectively. One of the lead SNPs in each of the cases with corneal astigmatism ≤  − 1.25 D and ≤  − 1.50 D, (a) rs7673984 and (b) rs11133315, respectively, is depicted as a purple diamond. The color coding for all other SNPs indicates linkage disequilibrium with (a) rs7673984 or (b) rs11133315 as follows: red, r² ≥ 0.8; yellow, 0.6 ≤ r² < 0.8; green, 0.4 ≤ r² < 0.6; cyan, 0.2 ≤ r² < 0.4; and blue, r² < 0.2. (Bottom row) Gene annotations.