Table 2 Association results for 13 genotyped SNPs in the PDGFRA gene region.

From: Association of PDGFRA polymorphisms with the risk of corneal astigmatism in a Japanese population

SNP

Position on Chr. 4 (GRCh37)

Alleles

(1 > 2)

Phenotype

N

Minor Allele Freq

P

Pc

OR (95% CI)

 

Criteria for CA (D)

rs11133315

55,082,158

G>A

Controls

Mean > − 0.75

842

0.178

   

Cases

Mean ≤ − 0.75

1535

0.196

0.16

 

1.12 (0.96–1.32)

Mean ≤ − 1.00

1134

0.209

0.021

0.19

1.23 (1.03–1.47)

Mean ≤ − 1.25

787

0.220

0.0028

0.026

1.34 (1.11–1.63)

Mean ≤ − 1.50

514

0.217

0.0043

0.038

1.39 (1.11–1.73)

rs7673984

55,088,761

C>T

Controls

Mean > − 0.75

842

0.156

   

Cases

Mean ≤ − 0.75

1535

0.177

0.079

 

1.17 (0.98–1.38)

Mean ≤ − 1.00

1134

0.188

0.012

0.11

1.26 (1.05–1.52)

Mean ≤ − 1.25

787

0.199

0.0018

0.016

1.38 (1.13–1.69)

Mean ≤ − 1.50

514

0.194

0.0062

0.055

1.39 (1.10–1.75)

rs4864857

55,089,814

T>C

Controls

Mean > − 0.75

842

0.156

   

Cases

Mean ≤ − 0.75

1535

0.177

0.079

 

1.17 (0.98–1.38)

Mean ≤ − 1.00

1134

0.188

0.012

0.11

1.26 (1.05–1.52)

Mean ≤ − 1.25

787

0.199

0.0018

0.016

1.38 (1.13–1.69)

Mean ≤ − 1.50

514

0.194

0.0062

0.055

1.39 (1.10–1.75)

rs6554162

55,093,955

G>A

Controls

Mean > − 0.75

842

0.284

   

Cases

Mean ≤ − 0.75

1535

0.301

0.19

 

1.10 (0.96–1.26)

Mean ≤ − 1.00

1134

0.313

0.035

0.32

1.18 (1.01–1.37)

Mean ≤ − 1.25

787

0.328

0.0072

0.065

1.26 (1.06–1.49)

Mean ≤ − 1.50

514

0.326

0.011

0.095

1.29 (1.06–1.56)

rs6554163

55,102,559

T>A

Controls

Mean > − 0.75

842

0.157

   

Cases

Mean ≤ − 0.75

1535

0.177

0.094

 

1.16 (0.97–1.37)

Mean ≤ − 1.00

1134

0.189

0.014

0.13

1.26 (1.05–1.51)

Mean ≤ − 1.25

787

0.199

0.0025

0.022

1.37 (1.12–1.67)

Mean ≤ − 1.50

514

0.194

0.0081

0.073

1.37 (1.09–1.73)

rs7677751

55,124,460

C>T

Controls

Mean > − 0.75

842

0.150

   

Cases

Mean ≤ − 0.75

1535

0.173

0.063

 

1.18 (0.99–1.40)

Mean ≤ − 1.00

1134

0.182

0.016

0.14

1.26 (1.04–1.51)

Mean ≤ − 1.25

787

0.192

0.0039

0.035

1.35 (1.10–1.66)

Mean ≤ − 1.50

514

0.186

0.0098

0.088

1.37 (1.08–1.73)

rs2303429

55,124,870

C>T

Controls

Mean > − 0.75

842

0.111

   

Cases

Mean ≤ − 0.75

1535

0.107

0.44

 

0.92 (0.76–1.13)

Mean ≤ − 1.00

1134

0.103

0.091

 

0.83 (0.66–1.03)

Mean ≤ − 1.25

787

0.102

0.062

 

0.79 (0.62–1.01)

Mean ≤ − 1.50

514

0.108

0.13

 

0.81 (0.61–1.07)

rs7656613

55,141,843

T>C

Controls

Mean > − 0.75

842

0.464

   

Cases

Mean ≤ − 0.75

1535

0.460

0.93

 

1.01 (0.89–1.14)

Mean ≤ − 1.00

1134

0.458

0.66

 

1.03 (0.90–1.18)

Mean ≤ − 1.25

787

0.449

0.61

 

1.04 (0.89–1.21)

Mean ≤ − 1.50

514

0.455

0.36

 

1.08 (0.91–1.29)

rs1547905

55,146,754

C>A

Controls

Mean > − 0.75

842

0.145

   

Cases

Mean ≤ − 0.75

1535

0.160

0.21

 

1.12 (0.94–1.33)

Mean ≤ − 1.00

1134

0.170

0.059

 

1.20 (0.99–1.44)

Mean ≤ − 1.25

787

0.179

0.033

0.30

1.25 (1.02–1.54)

Mean ≤ − 1.50

514

0.178

0.038

0.34

1.29 (1.01–1.63)

rs3816888

55,146,761

C>T

Controls

Mean > − 0.75

842

0.021

   

Cases

Mean ≤ − 0.75

1535

0.022

0.69

 

1.09 (0.71–1.69)

Mean ≤ − 1.00

1134

0.021

0.56

 

1.15 (0.72–1.85)

Mean ≤ − 1.25

787

0.020

0.54

 

1.18 (0.69–2.03)

Mean ≤ − 1.50

514

0.020

0.55

 

1.17 (0.70–1.98)

rs17739921

55,164,866

A>C

Controls

Mean > − 0.75

842

0.285

   

Cases

Mean ≤ − 0.75

1535

0.275

0.35

 

0.94 (0.81–1.07)

Mean ≤ − 1.00

1134

0.275

0.32

 

0.93 (0.80–1.08)

Mean ≤ − 1.25

787

0.274

0.22

 

0.90 (0.76–1.06)

Mean ≤ − 1.50

514

0.264

0.079

 

0.84 (0.69–1.02)

rs1826426

55,167,287

A>G

Controls

Mean > − 0.75

842

0.403

   

Cases

Mean ≤ − 0.75

1535

0.411

0.21

 

1.08 (0.96–1.23)

Mean ≤ − 1.00

1134

0.416

0.061

 

1.14 (0.99–1.31)

Mean ≤ − 1.25

787

0.402

0.31

 

1.08 (0.93–1.27)

Mean ≤ − 1.50

514

0.400

0.27

 

1.11 (0.92–1.32)

rs6554170

55,174,885

C>T

Controls

Mean > − 0.75

842

0.357

   

Cases

Mean ≤ − 0.75

1535

0.366

0.22

 

1.08 (0.95–1.23)

Mean ≤ − 1.00

1134

0.368

0.13

 

1.11 (0.97–1.28)

Mean ≤ − 1.25

787

0.352

0.59

 

1.04 (0.89–1.22)

Mean ≤ − 1.50

514

0.349

0.57

 

1.05 (0.88–1.27)

  1. SNP single-nucleotide polymorphism, 1 major allele, 2 minor allele, CA corneal astigmatism, Pc corrected P-value, OR odds ratio, CI confidence interval.
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