Figure 3 | Scientific Reports

Figure 3

From: Cancer-associated fibroblast-related prognostic signature predicts prognosis and immunotherapy response in pancreatic adenocarcinoma based on single-cell and bulk RNA-sequencing

Figure 3

Validation of the CAF marker gene prognostic signature in the ICGC dataset. (A) Division of PAAD patients in the ICGC dataset into high- and low-risk groups based on the median risk score in the TCGA cohort. (B) Distribution of survival status of high- and low-risk PAAD patients in the ICGC dataset (Blue dot: Alive, Red dot: Dead). (C) PCA plot based on the risk scores of PAAD patients in the ICGC dataset. (D) Kaplan–Meier analysis of OS of PAAD patients in the low- and high-risk subgroups, with comparisons by log-rank tests. (E) ROC curves for 1, 3, and 5 year overall survival of high- and low-risk PAAD patients in the ICGC dataset. (F) The relationship between CAF-associated prognostic subtypes (low-risk and high-risk group) and PDAC tumor subtypes (basal-like and classical group) in ICGC (P = 0.001).

Back to article page