Table 3 Results of multi-protein models evaluating the relationship between serum protein abundances and outcomes of interest.

From: Circulating biomarkers of extracellular matrix dysregulation are associated with adverse post-stage 2 outcomes in infants with single ventricle heart disease

Protein

Coefficient

p value

48h Low Sat% adjusted r2 = 0.361

 MMP 7

7.07

4.96 E-04

 MMP 17

5.53

3.33 E-03

 MMP 8

− 3.79

3.72 E-02

 FGFR2

− 3.51

5.79 E-02

 Growth index

4.64

1.52 E-02

Length of Stay adjusted r2 = 0.363

 MMP 7

7.63

2.16 E-02

 MMP 8

− 7.3

2.71 E-02

 MMP 1

− 12.31

4.43 E-04

 TIMP 4

12.51

3.30 E-04

  1. Proteins and clinical covariates associated with post-operative hypoxemia burden (top) and length of stay (bottom) in the final selected multi-protein model. Considered clinical covariates included demographic and diagnostic variables. Positive coefficients indicate a direct relationship between the candidate predictor and outcome of interest while negative coefficients indicate an inverse relationship. MMP = matrix metalloprotease, FGF = fibroblast growth factor, 48h low sat% = percent of the first 48 post-operative hours with oxygen saturation < 70%. Adjusted R2 value reflects results of the final selected model including all variables listed.
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