Figure 4 | Scientific Reports

Figure 4

From: Chronic dehydration induces injury pathways in rats, but does not mimic histopathology of chronic interstitial nephritis in agricultural communities

Figure 4

Evaluation of renal cortical atrophy. Whereas insignificant signs of atrophy were noted in control (A,B) and dehydrated (C,D) animals, atrophy clearly presented itself in the cyclosporin exposed group (E,F) in patches scattered throughout the cortex. The patches (marked by yellow lines) contain atrophic tubules with proximal epithelial cells filled with an increased number of enlarged argyrophilic granules in a context of mild interstitial fibrosis. (G) Area% of the combined atrophic patches over the delineated tissue (in red) consisting of cortex and the OSOM, but excluding medulla. Data presented as mean per animal ± SEM. ***P < 0.001.

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