Table 1 PFKFB4 expression and clinicopathological characteristics of patients with COAD.

From: Differential roles of highly expressed PFKFB4 in colon adenocarcinoma patients

Variables

Case, n

PFKFB4 expression

χ2

p-value

Low, n (7)

High, n (72)

Age, years

  ≤ 62

40

25 (62.50)

15 (37.50)

1.9420

0.1634

  > 62

39

30 (76.92)

9 (23.08)

  

Gender

 Male

36

27 (75.00)

9 (25.00)

0.9050

0.3414

 Female

43

28 (65.12)

15 (34.88)

  

Type

 Others colon

45

36 (88.00)

9 (20.00)

5.3260

0.0210a

 Sigmoid colon

34

19 (55.88)

15 (44.12)

  

Differentiation

 Well + Moderate

40

36 (72.00)

14 (28.00)

0.2381

0.6256

 Poor

27

18 (66.67)

9 (33.33)

  

 NA*

2

1 (50.00)

1 (50.00)

  

Tumor size, cm

 ≤ 4

45

32 (71.11)

13 (28.89)

0.1765

0.6744

 > 4

33

22 (66.67)

11 (33.33)

  

 NA*

1

1 (100.00)

0 (0.00)

  

pT stage

 T1 + 2

13

11 (84.62)

2 (15.38)

0.9750

0.3234

 T3 + 4

65

43 (66.15)

22 (33.85)

  

 NA*

1

1 (100.00)

0 (0.00)

  

pN stage

 N0

41

38 (74.51)

13 (25.49)

1.9270

0.1650

 N1 + 2

27

16 (59.26)

11 (40.74)

  

 NA*

1

1 (100.00)

0 (0.00)

  

pM stage

 M0

76

53 (69.74)

23 (30.26)

 

 > 0.9999b

 M1

3

2 (66.67)

1 (33.33)

  

Dukes stage

 A + B

49

3 (75.51)

12 (24.49)

2.44

0.1183

 C + D

29

17 (58.62)

12 (41.38)

  

 NA*

1

1 (100.00)

0 (0.00)

  
  1. aP < 0.05; bFisher’s exact test. NA, not applicable; *: means the degree of tumor differentiation, size, or stage of part of patients could not be defined. p, pathological; PFKFB4, phosphofructo‑2‑kinase/fructose‑2,6‑biphosphatase 4; COAD, colon adenocarcinoma.