Table 2 Molecular features of serum, oral fluid, and DBS samples.

From: Genetic diversity of hepatitis B virus quasispecies in different biological compartments reveals distinct genotypes

Sample

Genotype

Viral load (logUI/mL)

Substitutions

Polymerase

HBsAg

1808 serum

F2

2.37

N123D, M129L, S137T, L151F, N246S, T259S, D271E

A159G

1810 serum

F4

3.09

N33S, T118N, H122Y, N123D, Q149K, L151F, D271E

T23I, I25V, L110I, A159G

1823 serum

A1

2.29

N122H, M129L, N131D, V163I, I253V

T131N, S207N, V209L

1828 DBS

A1

NA

I53L, V112I, N122H, Y126C, M129L, V142A, V163I, Q215H, I253V

V96A, M103I, T118A, K122R, T131N, F134L, D144A, V168A, V180A, S207T

1828 oral fluid

A1

NA

I53L, V112I, N122H, Y126C, M129L, V142A, V163I, Q215H, I253V

V96A, M103I, T118A, K122R, T131N, F134L, D144A, V168A, V180A, S207T

1828 serum

A1

7.8

I53L, V112I, N122H, Y126C, M129L, V142A, V163I, Q215H, I253V

V96A, M103I, T118A, K122R, T131N, F134L, D144A, V168A, V180A, S207T

1837 DBS

D3

NA

L91I, F122L, Q130P, N131H, Y135S, C256S, D263E, I266V, V278I

A159G, S207N

1837 oral fluid

D3

NA

L91I, F122L, Q130P, N131H, Y135S, C256S, D263E, I266V, V278I

A159G, S207N

1837 serum

D3

7.09

L91I, F122L, Q130P, N131H, Y135S, C256S, D263E, I266V, V278I

A159G, S207N

1855 DBS

F2

NA

N123D, M129L, N131D, S137T, L151F, S213T, L220I, N246S, T259S, D271E, T313A

N40S, T45L, C76Y, P127L, A159G, N204K

1855 oral fluid

F2

NA

S74P, N123D, M129L, S137T, S213T, N246S, T259S, D271E, Q288H

T45L, Q101H, P127L, A159G, N204K

1855 serum

F2

6.04

N123D, M129L, N131D, S137T, L151F, S213T, L220I, N246S, T259S, D271E, T313A, I315IM

N40S, T45L, C76Y, P127L, A159G, N204K

1941 oral fluid

A2

NA

L217R, Q319K

T131N

1941 serum

A2

> 9

L217R, Q319K

T131N

1948 oral fluid

A2

NA

N122H, M129L, V163I

T131N, S207N, V209L

1948 serum

A1

7.54

N122H, M129L, V163I, A317S

T131N, S207N, V209L

2055 serum

A1

3.08

I53T, N122H, Y126H, M129L, V163I, I253V, D263E, H271Q

N40S, S45P, T131N, S174N, S207N, V209L

2056 DBS

A1

NA

N122H, M129L, W153R, V163I, I253V, V278I

T131N, S207N, V209L

2056 oral fluid

A1

NA

N122H, M129L, W153R, V163I, I253V, V278I

Q101H, T131N, S207N, V209L

2056 serum

A1

9

N122H, M129L, W153R, V163I, I253V, V278I

T131N, S207N, V209L

2063 serum

A1

4.55

I53S, N122H, M129L, V163I, N238Y, I253V

G44E, S45A, L49R, T131N, S207N, V209L

2064 DBS

A1

NA

R110G, N122H, M129L, V163I, I253V

L175S, T131N, S207N, V209L, P217L

2064 serum

A1

3.79

R110G, N122H, M129L, V163I, I253V

I68T, A194V, T131N, S207N, V209L

2065 DBS

A1

NA

N122H, M129L, W153RW, V163I, M171LM, Q215HQ, I253V, V278I

Y100C, T131N, E164EG, A194AV, S207NT, I208IT, V209L

2065 serum

A1

2.72

N122H, M129L, V163I, I253V

Y100C, T131N, A194AV, S207T, I208T, V209L

2069 serum

A1

7.3

I53V, N122H, M129L, W153R, S159T, V163I, S219A, I253V, V278I

L21S, L49R, I68T, Y100C, T131N, Y161F, S207N, I208T, V209L, S210R

2072 DBS

F2

NA

N123D, M129L, S137T, N246S, T259S, D271E, T313A

T45L, A159G, Y161F

2072 serum

F2

6.66

N123D, M129L, S137T, N246S, T259S, D271E, T313A

T45L, A159G, Y161F

2073 serum

A1

2.53

I53V, S117C, N122H, Q125K, M129L, V163I, I253V

R24K, L109V, T131N, V184A, T189I, S204N, S207N, I208T, V209L

2101 oral fluid

D3

NA

N53K, F122L, Q130P, Y135S, D263E, I266V, V278I

T45S, A159G

2101 serum

D3

8.66

N53K, F122L, Q130P, Y135S, D263E, I266V, V278I

T45S, A159G

LC04 DBS

A2

NA

I53INST, T54P, Q67KN, S68T, L217R

S45APST, P46HLPR, S58S, T131N, N59IKRT

LC04 serum

E

3.83

A313S

A159G

LC43 DBS

A1

NA

T53P, N123D, M129L, N134D, S137T, K212R, K241R, N246S, V253I, T259S, D271E

G44A, T45L, S55C, A159G, Y200S, N204D

LC43 serum

F2

2.8

T53P, N123D, M129L, S137T, K212R, K241R, N246S, V253I, T259S, D271E, T313A

T23I, G44A, T45L, S55C, T131N, Y200S, N204D

LC 87 serum

A1

3.26

N122H, M129L, W153R, V163I, I253V, V278I

Y100C, T131N, A194V, S207N, V209L

  1. NA Not available. Clinically relevant substitutions are highlighted in bold.