Figure 4

Manhattan plots of DGE p-values by LMM with the discovery RNA-Seq data of DLPFC tissue of \(\beta\)-amyloid (A) and global AD pathology burden (B). Top five significant DGEs were labeled. Red line indicates the significant threshold 3.49 × 10–6 with Bonferroni correction and blue line indicates p-value = 0.0001.