Table 3 LMM P-values of 10 replicated DGEs (p-value < 0.5/37 = 0.00135) using the validation ROS/MAP RNA-Seq data of DLPFC.

From: Differential gene expression analysis based on linear mixed model corrects false positive inflation for studying quantitative traits

Gene name

CHR

Cognitive decline

\(\beta\)-Amyloid

Tangle density

Global AD pathology

PTPRF

1

2.74 × 10–1

1.62 × 10–2

1.68 × 10–2

1.25 × 10–3*

NPNTa

4

3.82 × 10–6*

1.22 × 10–4*

1.05 × 10–10*

3.84 × 10–10*

ADAMTS2a

5

7.20 × 10–5*

4.33 × 10–1

3.14 × 10–2

2.14 × 10–1

PGM3

6

3.89 × 10–2

9.08 × 10–4*

3.50 × 10–3

3.70 × 10–3

TRIP6

7

6.28 × 10–2

6.79 × 10–2

6.92 × 10–6*

6.34 × 10–4*

PLCE1

10

4.02 × 10–1

2.55 × 10–3

2.66 × 10–3

4.51 × 10–4*

CD44

11

1.22 × 10–2

9.63 × 10–1

4.47 × 10–4*

7.39 × 10–2

RERGa

12

7.21 × 10–3

9.08 × 10–5*

1.08 × 10–7*

5.45 × 10–7*

PLCD3

17

3.70 × 10–1

1.13 × 10–3*

4.05 × 10–3

5.42 × 10–5*

MEIS3

19

2.31 × 10–5*

5.58 × 10–2

5.18 × 10–4*

5.92 × 10–4*

  1. aSignificant DGEs with Bonferroni correction (p-value < 2.89 × 10–6).
  2. *Indicating the corresponding trait (columns 3–6) for which the potential DGE was replicated (p-value < \(1.35\times {10}^{-3}\)).
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