Table 4 LMM P-values of 11 replicated DGEs (p-value < 0.05) using the validation ROS/MAP RNA-Seq data of SMA, spinal cord and muscle tissues.

From: Differential gene expression analysis based on linear mixed model corrects false positive inflation for studying quantitative traits

Tissue

Gene name

CHR

Cognitive decline

\(\beta\)-Amyloid

Tangle density

Global AD pathology

SMA

PTPRF

1

0.201

0.015*

0.589

0.122

NPNT

4

0.121

0.463

0.011*

0.147

ADAMTS2a

5

0.001*

0.014*

3.0 × 10–5*

0.001*

HRSP12a

8

4.4 × 10–5*

0.010*

0.028*

0.007*

PLCE1

10

0.056

0.935

0.016*

0.106

RERG

12

0.05

0.141

0.048*

0.122

CPM

12

0.3

0.165

0.003*

0.011*

ALDH6A1

14

0.008*

0.196

0.05

0.049*

Spinal cord

APOBR

6

0.7

0.153

0.135

0.039*

APLNR

11

0.17

0.035*

0.114

0.06

Muscle

C3orf58

3

0.033*

0.389

0.222

0.478

APLNR

11

0.22

0.015*

0.505

0.127

ALDH6A1

14

0.043*

0.352

0.204

0.121

  1. aSignificantly replicated DGEs with p-value < 0.001.
  2. *Indicating the corresponding trait (columns 4–7) for which the potential DGE was replicated (p-value < 0.05).
Back to article page