Table 4 Univariable generalized mixed model for fixed effects logit link function to assess the impact of baseline variables on the a significant increase in ICP (increase of more than 20% of baseline or increased that resulted in ICP > 20 mmHg) after positive end expiratory pressure (PEEP) increments.

From: The effect of increased positive end expiratory pressure on brain tissue oxygenation and intracranial pressure in acute brain injury patients

 

Univariable analysis OR (95% CI)

P value

Age, year

0.998 (0.979–1.018)

0.83

Male sex

1.136 (0.634–2.036)

0.67

Glasgow Coma Scale on admission

1.003 (0.928–1.085)

0.93

SOFA score at ICU admission

1.087 (0.955–1.237)

0.99

TBI compared to SAH

0.614 (0.330–1.144)

0.13

Baseline PEEP

1.039 (0.937–1.152)

0.46

Baseline ICP

0.963 (0.917–1.011)

0.13

Baseline CPP

1.006 (0.990–1.021)

0.47

Baseline PbtO2

0.988 (0.960–1.017)

0.40

Baseline PaO2

0.998 (0.992–1.004)

0.49

Baseline PaCO2

1.023 (0.993–1.054)

0.14

  1. Data are expressed as odds ratio and 95% confidence intervals. Data from 112 patients with 295 episodes of PEEP incrementation were included in this analysis.
  2. SOFA sequential organ failure assessment, ICU intensive care unit, TBI traumatic brain injury, SAH subarachnoid hemorrhage, PEEP positive end expiratory pressure, ICP intracranial pressure, CPP cerebral perfusion pressure, PbtO2 brain tissue partial pressure of oxygen, PaO2 arterial partial pressure of oxygen, PaCO2 arterial partial pressure of carbon dioxide.
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