Figure 3 | Scientific Reports

Figure 3

From: A protein kinase C α and β inhibitor blunts hyperphagia to halt renal function decline and reduces adiposity in a rat model of obesity-driven type 2 diabetes

Figure 3The alternative text for this image may have been generated using AI.

Cmpd 1 administration decreases food consumption and causes weight loss in ZSF1 obese animals. (a) Results from 4 day pharmacokinetic (PK) study for free (i.e., corrected for plasma protein binding) serum drug concentrations in the morning (9 a.m.) and late afternoon (4 p.m.) with chow dosing of Cmpd 1. Estimated food consumption (b) and % weight gain (c) over 7 days for ZSF1 obese, ZSF1 lean, or SD rats fed either no-drug chow or Cmpd 1 chow (n = 3 animals for each ZSF1 group; n = 2 animals for SD group). (d) Average food consumption of no-drug chow (left y-axis; closed circles) and % weight gain (right y-axis; open circles) of ZSF1 obese rats dosed daily with 100 mpk/day Cmpd 1 by oral gavage (n = 5 animals). Weights were measured on days 2, 4, 6, and 7.

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