Figure 4 | Scientific Reports

Figure 4

From: A protein kinase C α and β inhibitor blunts hyperphagia to halt renal function decline and reduces adiposity in a rat model of obesity-driven type 2 diabetes

Figure 4The alternative text for this image may have been generated using AI.

Study groups, food consumption, and body weight over the course of a 10-week Cmpd 1 administration study in ZSF1 obese rats. Animals were 21–22 weeks of age at study start. All groups were maintained on normal Purina 5008 chow for the 10-week study except the Cmpd 1 group, which was provided Purina 5008 chow formulated with 0.744 g Cmpd 1 per kg chow (approximatley 50 mpk/day Cmpd 1 administration; a). The amount of food provided each week to the Food matched group was determined by the estimated food consumption by the Cmpd 1 group the previous week. For all three ZSF1 obese groups, 3 animals were taken down at study mid-point for an interim analysis. (b) Average food consumption for all animals over the study duration as estimated by amount of food provided versus food remaining in the hopper for the indicated intervals. (c) Average body weight over the study duration for all animals. (d) Average body weights at study start and study termination (interim animals excluded), with average weights indicated numerically above the bars.

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