Table 3 Size (nm) values of solid lipid nanoparticles (SLN) composed of stearic or arachidic acids, without contact with blood, with contact with blood but where no incubation was allowed to occur (0 h of incubation) and after 3 h, 6 h, 9 h, 12 h and 24 h of incubation in blood, n = 3.

SLN		Size (nm)	SEM	P value
Control		6^a*	3
Stearic acid	Without contact with the blood	454^b	38	< 0.001
	After 0 h of incubation	361^bc
	After 3 h of incubation	295^c
	After 6 h of incubation	293^c
	After 9 h of incubation	278^c
	After 12 h of incubation	275^c
	After 24 h of incubation	11^a
Arachidic acid	Without contact with the blood	401^b	21	< 0.001
	After 0 h of incubation	402^b
	After 3 h of incubation	325^ce
	After 6 h of incubation	377^bef
	After 9 h of incubation	294^cd
	After 12 h of incubation	326^cf
	After 24 h of incubation	243^d#

SEM standard error of the mean.
*This value is indicative of no present SLN (but of naturally occurring particles in suspension in the blood) as they were not added to the control.
^#This value is not indicative of the total replicate populations, as in some of them no SLN were detected, indicating a possible destruction;
Different superscript letters indicate significant differences (P ≤ 0.05) between the negative control (blood without SLN addition) and each SLN at all timepoints. Stearic or arachidic acid SLN were compared only with the negative control and not with each other.

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