Table 1 Comparison of demographic characteristics and comorbidities between type 2 diabetes mellitus patients treated with or without sodium-glucose cotransporter 2 inhibitors.
Variables | Non-SGLT2is (N = 85,550) | SGLT2is (N = 85,550) | SMD | ||
|---|---|---|---|---|---|
N | % | N | % | ||
Sex | 0.009 | ||||
Female | 38,323 | 44.80 | 37,936 | 44.34 | |
Male | 47,227 | 55.20 | 47,614 | 55.66 | |
Age | |||||
40–59 | 38,294 | 44.76 | 38,512 | 45.02 | 0.005 |
60–79 | 44,560 | 52.09 | 44,290 | 51.77 | 0.006 |
≥ 80 | 2696 | 3.15 | 2748 | 3.21 | 0.003 |
Mean (SD) | 60.86 | 9.77 | 60.74 | 9.77 | 0.012 |
Income | |||||
< 20,000 | 17,081 | 19.97 | 17,001 | 19.87 | 0.002 |
20,000–39,999 | 46,004 | 53.77 | 46,014 | 53.79 | < 0.001 |
≥ 40,000 | 22,465 | 26.26 | 22,535 | 26.34 | 0.002 |
Comorbidity | |||||
Hypertension | 66,140 | 77.31 | 65,877 | 77.00 | 0.007 |
Dyslipidemia | 74,263 | 86.81 | 73,779 | 86.24 | 0.017 |
CAD | 25,923 | 30.30 | 26,241 | 30.67 | 0.008 |
CVA | 10,970 | 12.82 | 11,268 | 13.17 | < 0.001 |
Liver cirrhosis | 988 | 1.15 | 1185 | 1.39 | 0.021 |
CKD | 5157 | 6.03 | 5335 | 6.24 | 0.009 |
Obesity | 3250 | 3.80 | 3387 | 3.96 | 0.008 |
Smoking | 3511 | 4.10 | 3610 | 4.22 | 0.006 |
DCSI score | |||||
0–1 | 18,383 | 21.49 | 17,853 | 20.87 | 0.015 |
2 | 17,408 | 20.35 | 17,413 | 20.35 | < 0.001 |
≥ 3 | 49,759 | 58.16 | 50,284 | 58.78 | 0.012 |
Anti-diabetic medications | |||||
Sus | 66,094 | 53.77 | 64,995 | 52.88 | 0.030 |
TZDs | 26,438 | 21.51 | 25,964 | 21.12 | 0.012 |
GLP1Ras | 1537 | 1.25 | 1625 | 1.32 | 0.008 |
DPP4is | 28,844 | 23.47 | 26,876 | 21.87 | 0.047 |
Types of anti-diabetic medications | |||||
1 | 46,900 | 54.82 | 49,771 | 58.18 | 0.068 |
2 | 27,533 | 32.18 | 25,948 | 30.33 | 0.040 |
≥ 3 | 11,117 | 12.99 | 9831 | 11.49 | 0.046 |
Follow up period, mean (SD) | |||||
T2DM | 6.79 | 2.71 | 7.78 | 2.38 | 0.387 |
Diabetic retinopathy | 2.32 | 0.84 | 2.29 | 0.77 | 0.045 |