Table 3 The top 20 genes significantly up-regulated in HR-NB vs. LIR-NB.

From: Joint analysis of the metabolomics and transcriptomics uncovers the dysregulated network and develops the diagnostic model of high-risk neuroblastoma

No

Gene

Description

Fold Change

P value

1

H4C3

H4 clustered histone 3

30.916

3.43E−08

2

THRSP

Thyroid hormone responsive

25.793

1.70E−09

3

TRARG1

Trafficking regulator of GLUT4 (SLC2A4) 1

21.326

3.84E−06

4

CYP21A2

Cytochrome P450 family 21

Subfamily A member 2

20.358

7.25E−10

5

CIDEC

Cell death inducing DFFA like effector c

18.992

6.04E−07

6

DES

Desmin

18.251

5.47E−12

7

DPT

Dermatopontin

18.023

6.90E−12

8

S100A12

S100 calcium binding protein A12

17.576

2.00E−11

9

H1-4

H1.4 linker histone, cluster member

17.292

1.23E−07

10

DLK1

Delta like non-canonical Notch ligand 1

16.116

2.76E−10

11

MRAP

Melanocortin 2 receptor accessory protein

15.255

4.62E−07

12

PLIN1

Perilipin 1

15.235

2.36E−08

13

NTS

Neurotensin

15.205

3.23E−08

14

GPD1

Glycerol-3-phosphate dehydrogenase 1

14.816

7.06E−10

15

FABP4

Fatty acid binding protein 4

14.238

3.53E−10

16

SFRP2

Secreted frizzled related protein 2

13.779

3.78E−09

17

PRG2

Proteoglycan 2, pro eosinophil

major basic protein

13.389

1.36E−10

18

FAM166B

Family with sequence

Similarity 166 member B

11.802

2.98E−09

19

HBB

Hemoglobin subunit beta

10.902

2.01E−11

20

MGST1

Microsomal glutathione S-transferase 1

10.654

4.85E−08