Table 4 The top 20 genes significantly down-regulated in HR-NB vs. LIR-NB.

From: Joint analysis of the metabolomics and transcriptomics uncovers the dysregulated network and develops the diagnostic model of high-risk neuroblastoma

No

Gene

Description

Fold change

P value

1

TMEM163

Transmembrane protein 163

0.281

2.66E−06

2

UNC5D

unc-5 netrin receptor D

0.281

0.000631

3

VWDE

von Willebrand factor D

and EGF domains

0.280

0.000974

4

ZCCHC12

Zinc finger CCHC-type containing 12

0.270

0.000174

5

SLC5A7

Solute carrier family 5 member 7

0.263

0.001530

6

GRIN3A

glutamate ionotropic receptor

NMDA type subunit 3A

0.263

0.000867

7

TPBGL

Trophoblast glycoprotein like

0.254

2.42E−08

8

GFAP

Glial fibrillary acidic protein

0.250

0.002749

9

SST

somatostatin

0.249

0.001242

10

CDH10

Cadherin 10

0.236

0.000629

11

HTR1B

5-Hydroxytryptamine receptor 1B

0.222

0.000863

12

SPHKAP

SPHK1 interactor, AKAP

domain containing

0.220

5.53E−05

13

LRRTM3

Leucine rich repeat

Transmembrane neuronal 3

0.193

7.60E−05

14

UPP2

Uridine phosphorylase 2

0.193

6.05E−08

15

UTS2

Urotensin 2

0.168

3.07E−05

16

DPP10

Dipeptidyl peptidase like 10

0.128

6.47E−06

17

UCN3

Urocortin 3

0.118

3.34E−07

18

ADCYAP1

Adenylate cyclase activating

Polypeptide 1

0.112

1.04E−06

19

GRP

Gastrin releasing peptide

0.084

5.88E−06

20

CGA

Glycoprotein hormones,

Alpha polypeptide

0.062

4.93E−09