Figure 4 | Scientific Reports

Figure 4

From: Tumor microenvironment heterogeneity in bladder cancer identifies biologically distinct subtypes predicting prognosis and anti-PD-L1 responses

Figure 4

Associations between subtypes and anti-PD-L1 responses. (A) Response rates of C1 (34%), C2 (22%), and C3 (14%) subtypes. (B) Violin diagrams indicate abundance of PD-L1 mRNA in three subtypes. C3 subtype had the lowest PD-L1 mRNA abundance. (C) Immunohistochemical findings of PD-L1 expression in immune cells (ICs) among subtypes IC0 (< 1%), IC1 (≥ 1% but < 5%), and IC2 + (≥ 5%). (D) PD-L1 Immunohistochemical findings of PD-L expression in tumor cells (TCs) among subtypes, TC0 (< 1%), TC1 (≥ 1% but < 5%), and TC2 + (≥ 5%). (E) Differentially expressed genes divided into eight modules by WCGNA. (F) Heatmap of corresponding correlation coefficients and p-values between modules and groups. Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis based on genes in turquoise (G), black (H), pink (I), and yellow (J) modules Terms with p < 0.05 significantly differed.

Back to article page